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RANK/Fc Chimera from mouse
| 产品编号： | 3213784 |
| 规格： | ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture |
| 包装规格： | 0.1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
RANK/Fc Chimera from mouse
Osteoclast differentiation receptor, ODFR
Receptor activator of NF-κB
基本信息
| MDL number | MFCD03703131 |
| NACRES | NA.32 |
| Application【应用】 | RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF- |
| Biochem/physiol Actions【生化/生理作用】 | TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline. |
| Analysis Note【分析说明】 | The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| recombinant【重组】 | expressed in NSO cells |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | 10.12 μg/mL EC50 |
| mol wt【分子量】 | 60 kDa |
| packaging【包装】 | pkg of 1 mg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | O35305 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Tnfrsf11a(21934) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
