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H-7 dihydrochloride
产品别名
108930-17-2
H-7 dihydrochloride
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride
Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H17N3O2S · 2HCl |
| Molecular weight | 364.29 |
| Beilstein | 5840763 |
| MDL number | MFCD00036961 |
| PubChem Substance ID【PubChem化学物质编号】 | 24278496 |
| NACRES | NA.77 |
| General description【一般描述】 | H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β). |
| Application【应用】 | H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor. |
| Biochem/physiol Actions【生化/生理作用】 | Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C. |
| Caution【注意】 | Light sensitive |
产品性质
| Quality Level【质量水平】 | 200 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| solubility【溶解性】 | H2O: 20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23 |
| InChI | 1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H |
| InChI key | OARGPFMFRLLKPF-UHFFFAOYSA-N |
| Gene Information | human ... PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584) |
| packaging【包装】 | 5 mg in glass bottle 25 mg in poly bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
