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γ Secretase Inhibitor
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H41N3O5 |
| Molecular weight | 475.62 |
| NACRES | NA.32 |
| Amino Acid Sequence | Z-Leu-Leu-Nle-al |
| General description【一般描述】 | Gamma-secretase is a protein complex containing presenilin, nicastrin, APH-1, and PEN-2. The leupeptin analogue Z-Leu-Leu-Nle-al (N-benzyloxycarbonyl-Leu-Leu-norleucinal; Benzyloxicarbonyl-Leu-Leu-Nle-CHO (LLNle)) and closely related peptides are used as protease and a gamma secretase inhibitors. |
| Application【应用】 | γ Secretase Inhibitor has been used to study the suppressive miR-129 functions through inhibition on estrogen receptor 1 (ESR1) and NOTCH signaling in breast cancer stem cells. |
产品性质
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | lyophilized |
| composition【组成】 | Peptide Content, ≥85% |
| storage condition【储存条件】 | protect from light |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
