CP-31398 二盐酸盐 水合物

C₂₂H₂₆N₄O·2HCl · xH₂O

435.39 (anhydrous basis)

MFCD17215956

329823707

NA.77

CP-31398 dihydrochloride hydrate has been used as a p53 stabilizer:

• to evaluate its effects on the upregulation of miRNA in human neuroblastoma cells
• to study its effects on arsenic trioxide (ATO) stabilization of p53 folding
• to study its effects on regulation of miR-34 in PC12 cells

CP-31398 is a styryl quinazoline that functions in preserving the activity of p53 as a tumor suppressor and transcription factor. The DNA-binding activity and apoptosis functionality of the p53 are restored by CP-31398. CP-31398 exhibits therapeutic effects against liver, skin, pancreatic, and colon cancers.
CP-31398 dihyrochloride hydrate is a p53 stabilizer; apoptosis inducer.

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Pfizer for Apoptosis & Cell Cycle research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

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Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

100

≥98% (HPLC)

Pfizer^®

desiccated

yellow

H₂O: ≥20 mg/mL

Pfizer

2-8℃

O.Cl.Cl.COc1ccc(cc1)\C=C\c2nc(NCCCN(C)C)c3ccccc3n2

1S/C22H26N4O.2ClH.H2O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H;1H2/b14-11+;;;

JXIVIAMOMIONKY-UWCBQFGESA-N

human ... TP53(7157)
mouse ... TP53(22059)
rat ... TP53(24842)

5, 25 mg in glass bottle

GHS07

Warning

H302 - H315 - H319 - H413

P305 + P351 + P338

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2

13 - Non Combustible Solids

WGK 3